Extended ASE fate decision model (2010)

Summary of the regulatory interactions that determine ASEL/ASER fate

(a) Two ASE neurons. ASE senses different ions and expresses distinct ASEL/ASER-specific terminal fate markers, encoded by gcy and flp family genes. Photomicrographs of ASEL/ASER-specific gcy gene expressions in wild type are adapted from Hobert, 2006, Cold Spring Harbor Laboratory Press ©2006. (b) Biological diagram of ASE neuron fate decision pathway which takes into account additional regulator, fozi-1 (highlighted) and fozi-1 related regulations. Broken line denotes partially penetrant defect in maintaining the left/right asymmetric expression of loop component. Genes in inactive or active state are shown in grey or black, respectively. Four regulatory factors lsy-6, cog-1, die-1 and mir-273 form a double-negative feedback loop (DNFL). The expressions of flp-20/flp-4 and gcy-6/gcy-7 are ASEL-specific terminal fate markers, while the expressions of gcy-5/gcy-22 and hen-1 are used as ASER fate markers.

The HFPNe model of ASE fate decision pathway in wild-type

Download Related Files for Parameter Estimation and Online Model Checking

Extended model for parameter estimation (Structure + partial kinetic parameters) [2010-10-29]

The extended model, i.e., the whole model, which emulates nine genetic conditions including not only wild-type but also the combinations of five mutants, '''fozi-1(cc607)''', '''die-1(ot26)''', '''lsy-6(ot71)''', '''cog-1(sy607)''' and '''lim-6(nr2073)'''. The whole ASE model is composed of 474 entities, 1,026 processes and 1,620 connectors (totally 3,327 components).

The whole HFPNe model for model checking

Model14 in CSML3.0 version [2010-10-29]

Online model checker: MIRACH 1.0