EGFR Pathway
DOWNLOAD the Model
CSML1.9 version: ZIP | CSML [2007-06-05]
CSML3.0 version: ZIP | CSML [2008-01-31]
Launch on CIOPlayer [2009-12-25]
Launch on CIO [2009-12-25]
EGFR signal pathway model
- Supplemental information of the paper Modeling and Estimation of Dynamic EGFR Pathway by Data Assimilation Approach Using Time Series Proetomic Data.
- Shinya Tasaki, Masao Nagasaki, Masaaki Oyama, Hiroko Hata, Kazuko Ueno, Ryo Yoshida, Tomoyuki Higuchi, Sumio Sugano, and Satoru Miyano
Overview of EGFR signal pathway model
Supplementat
Supplemental All CSML models and parameters that were used in this paper with the CSML format and the Excel format (xls).
| Name | Excel format | CSML1.9 Model | Add/Remove | Description |
|---|---|---|---|---|
| model 1 |  model 1 | model1 | -(original) | Original model. |
| model 2 | model 2 | model2 | add | p38MAPK directly inactivates MKK3/4/6/7. |
| model 3 | model 3 | model3 | add | Erk2 directly inactivates MKK3/4/6/7. |
| model 4 | model 4 | model4 | add | p38MAPK itself activates the phosphatase of p38MAPK. |
| model 5 | model 5 | model5 | add | Erk2 directly activates the phosphatase of p38MAPK. |
| model 6 | model 6 | model6 | add | The combination of model 2 and model 4. |
| model 7 | model 7 | model7 | add | The combination of model 3 and model 5. |
| model 8 | model 8 | model8 | add | The combination of model 2 and model 5. |
| model 9 | model 9 | model9 | add | The combination of model 3 and model 4. |
| model 10 | model 10 | model10 | remove(control) | The activation process of Rac/Cdc42 by Vav2 is removed. |
Snapshot of whole network on Cell Illustrator [#a20ee89e]
