EGFR Pathway

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CSML1.9 version: ZIP | CSML [2007-06-05]
CSML3.0 version: CSML.GZ | CSML [2011-02-09] (work on CIO4.0 and CIO5.0)
Launch on CIOPlayer [2009-12-25]
Launch on CIO [2009-12-25]

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EGFR signal pathway model

  • Supplemental information of the paper Modeling and Estimation of Dynamic EGFR Pathway by Data Assimilation Approach Using Time Series Proetomic Data.
    • Shinya Tasaki, Masao Nagasaki, Masaaki Oyama, Hiroko Hata, Kazuko Ueno, Ryo Yoshida, Tomoyuki Higuchi, Sumio Sugano, and Satoru Miyano

Overview of EGFR signal pathway model

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Supplementat

Supplemental All CSML models and parameters that were used in this paper with the CSML format and the Excel format (xls).

NameExcel formatCSML1.9 ModelAdd/RemoveDescription
model 1 model 1 model1-(original)Original model.
model 2 model 2 model2addp38MAPK directly inactivates MKK3/4/6/7.
model 3 model 3 model3addErk2 directly inactivates MKK3/4/6/7.
model 4 model 4 model4addp38MAPK itself activates the phosphatase of p38MAPK.
model 5 model 5 model5addErk2 directly activates the phosphatase of p38MAPK.
model 6 model 6 model6addThe combination of model 2 and model 4.
model 7 model 7 model7addThe combination of model 3 and model 5.
model 8 model 8 model8addThe combination of model 2 and model 5.
model 9 model 9 model9addThe combination of model 3 and model 4.
model 10 model 10 model10remove(control)The activation process of Rac/Cdc42 by Vav2 is removed.

Snapshot of whole network on Cell Illustrator [#a20ee89e]