Endothelial cell (Angiogenesis)

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CSML1.9 version: ZIP | CSML [2007-06-05]
CSML3.0 version: ZIP | CSML [2008-01-31]
Launch on CIOPlayer [2009-12-24]
Launch on CIO [2009-12-24]

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  • Created by Euna Jeong.

Description

Endothelial cells receive multiple information from their environment that eventually leads them to progress along all the stages of the process of formation of new vessels. Angiogenic signals promote endothelial cell proliferation, increased resistance to apoptosis, changes in proteolytic balance, cytoskeletal reorganization, migration and, finally, differentiation and formation of a new vascular lumen. The main signaling cascades become activated in angiogenic endothelial cells as well as the opportunities of modulating angiogenesis through pharmacological interference with these signaling mechanisms. The mitogen-activated protein kinases pathway is very important in the transduction of proliferation signals; the phosphatidylinositol-3-kinase/protein kinase B signaling system, particularly essential for the survival of the angiogenic endothelium; the small GTPases involved in cytoskeletal reorganization and migration; and the kinases associated to focal adhesions which contribute to integrate the pathways from the two main sources of angiogenic signals, i. e. growth factors and the extracellular matrix. (from Ref 1)

References

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[2] Jones N and Dumont DJ, The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R, Oncogene, 17:1097-1108, 1998.

[3] Wajih N and Sane DC, Angiostatin selectively inhibits signaling by hepatocyte growth factor in endothelial and smooth muscle cells, Blood, 101:1857-1863, 2003.

[4] Leu SJ, Lam SC and Lau LF, Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells, J. Biol. Chem., 277:46248-46255, 2002

[5] Savani RC, Cao G, Pooler PM, Zaman A, Zhou Z and DeLisser HM, Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis, J. Biol. Chem., 276:36770-36778, 2001.

[6] Kobayashi H, Suzuki M, Kanayama N, Nishida T, Takigawa M and Terao T, CD44 stimulation by fragmented hyaluronic acid induces upregulation of urokinase-type plasminogen activator and its receptor and subsequently facilitates invasion of human chondrosarcoma cells, Int. J. Cancer., 102:379-389, 2002.

[7] Vanhaesebroeck B and Alessi DR, The PI3K-PDK1 connection: more than just a road to PKB, Biochem. J., 346:561-576, 2000.

[8] Vincent L, Soria C, Mirshahi F, Opolon P, Mishal Z, Vannier JP et al, Cerivastatin, an inhibitor of 3-hydroxy- 3-methylglutaryl coenzyme a reductase, inhibits endothelial cell proliferation induced by angiogenic factors in vitro and angiogenesis in in vivo models, Arterioscler. Thromb. Vasc. Biol., 22: 623-629, 2002.

[9] Kiosses WB, Shattil SJ, Pampori N and Schwartz MA, Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration, Nat. Cell Biol., 3:316-320, 2001.

[10] Kim YM, Hwang S, Kim YM, Pyun BJ, Kim TY, Lee ST et al, Endostatin blocks vascular endothelial growth factor-mediated signaling via direct interaction with KDR/Flk-1, J. Biol. Chem., 277:27872-27879, 2002.

[11] Zhong J, Eliceiri B, Stupack D, Penta K, Sakamoto G, Quertermous T et al, Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1, J. Clin. Invest. 112:30-41, 2003.