Endothelial cell (Extravasation)

Content

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CSML1.9 version: ZIP | CSML [2007-06-05]
CSML3.0 version: ZIP | CSML [2008-01-29]
Launch on CIOPlayer [2009-12-25]
Launch on CIO [2009-12-25]

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  • Created by Euna Jeong.

Description

This model is created based on the article [1]. The article's abstract is as follow:

Tumor necrosis factor (TNF) is the prototypic proinflammatory cytokine and endothelial cells are the principal cellular targets of its actions. Here I review the responses of endothelial cells to TNF, with emphasis on the induction of endothelial leukocyte adhesion molecules. I focus on the biochemistry and cell biology of signal transduction in TNF-treated endothelial cells that lead to the expression of adhesion molecules.

References

1. Pober, J., Endothelial activation: intracellular signaling pathways. Arthritis Research 2002; 4(3):S109-116.